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This teamwork, called metabolic cross-feeding, is active in most human stool samples tested, and the gene that starts it is over-represented in the microbiomes of colorectal cancer patients

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Key external factors such as persistent antigen exposure, immune checkpoint signaling, and the cytokine milieu, as well as intrinsic changes such as altered metabolic processes, epigenetic modifications, and transcriptional reprogramming, contribute to T cell dysfunction